Protein Details: Neuronal acetylcholine receptor subunit alpha-5

Protein ID

ICDB_Pro_0475

Protein Name

Neuronal acetylcholine receptor subunit alpha-5

Gene Name

CHRNA5; NACHRA5

Organism

Homo sapiens (Human)

Length

468 amino acids

AlphaFoldDB

AF-P30532-F1-model_v4.pdb

Function

After binding acetylcholine;the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Smoking As A Quantitative Trait Locus 3 and Primary Thrombocytopenia

Location

DOI ID

10.1016/0896-6273(90)90344-f; 10.1016/0896-6273(90)90031-a; 10.1002/j.1460-2075.1992.tb05554.x; 10.1073/pnas.82.15.5208; 10.1038/353846a0; 10.1038/359500a0